abstract：Previous literature has focused on either the direct or indirect contribution of cultural and creative industries (CCI) firms to the innovation capability of the wider economy, while the reverse approach, that is, the effect of region on CCI firms’ innovation, has been completely neglected. In this paper, it is argued that the innovative performance of CCI firms with an academic origin (CCI-USOs) may be influenced by the regional context where they operate. In so doing, it is defended that the study of innovation in CCI firms can be advanced through the development of a more integrative framework. Relying on a sample of 92 Spanish CCI-USOs over the period 2001–2010 and applying multilevel modelling, this study sheds light on how regional and firm level factors simultaneously impact on CCI-USOs’ innovation. The findings show that the regional context determines the innovative performance of CCI-USOs. In addition, firm age has a negative effect on the probability of having patent activity, while firm size and venture capital exerts a positive influence on innovative performance. On the basis of these results, some policies for fostering innovation in CCIs are proposed.

key word:Cultural and Creative Industries;Firms;University spin-offs;Innovation;Knowledge spillovers;Regional effect;Multilevel analysis